State of the art desmosine measurements with the gold standard LC-MS/MS method.
Desmosine is a special amino acid unique to mature cross-linked elastin. Therefore, Desmosine levels in plasma, urine and sputum are specifically reflecting mature elastin breakdown.
An COPD-activity- biomarker is urgently needed to detect early disease before irreversible lung destruction has developed, for prognosis and to efficiently quantify therapeutic effects on e.g. disease progression in cohorts and individual patients. Lung function tests do not fulfill the requirements for an activity biomarker in COPD.
Desmosine is only a valuable biomarker for elastin degradation when Desmosine is measured reliably.
we offer reliable measurement of desmosine using liquid chromatography-tandem mass spectrometry
Although chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) seem to be opposite entities from a clinical perspective, common initial pathogenic steps have
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Although cigarette smoking is the most important risk factor, not all
The RAPID trial is the single largest randomized placebo-controlled trial of alpha1-antitrypsin augmentation therapy completed to date. Ma et al. measured plasma desmosine levels in