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1. Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis. de Brouwer B, Drent M, van den Ouweland JMW, Wijnen PA, van Moorsel CHM, Bekers O, Grutters JC, White ES, Janssen R. Respir Res. 2018 Mar 20;19(1):45. [PubMed]

2. A pilot clinical trial to determine the safety and efficacy of aerosolized hyaluronan as a treatment for COPD. Cantor J, Ma S, Turino G. Int J Chron Obstruct Pulmon Dis. 2017 Sep 18;12:2747-2752. [PubMed]

3. The Effect of Alpha-1 Proteinase Inhibitor on Biomarkers of Elastin Degradation in Alpha-1 Antitrypsin Deficiency: An Analysis of the RAPID/RAPID Extension Trials. Ma S, Lin YY, Cantor JO, Chapman KR, Sandhaus RA, Fries M, Edelman JM, McElvaney G, Turino GM. Chronic Obstr Pulm Dis. 2016 Nov 18;4(1):34-44. [PubMed]

4. Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease. Huang JT, Bolton CE, Miller BE, Tal-Singer R, Rabinovich RA, Palmer CN, Thomson NC, MacNee W; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators. Eur Respir J. 2016 Oct;48(4):1215-1218. [PubMed]

5. Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in COPD. Rabinovich RA, Miller BE, Wrobel K, Ranjit K, Williams MC, Drost E, Edwards LD, Lomas DA, Rennard SI, Agustí A, Tal-Singer R, Vestbo J, Wouters EF, John M, van Beek EJ, Murchison JT, Bolton CE, MacNee W, Huang JT; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators. Eur Respir J. 2016 May;47(5):1365-73. [PubMed]

6. Elastin degradation: an effective biomarker in COPD. Turino GM, Lin YY, He J, Cantor JO, Ma S. COPD. 2012 Aug;9(4):435-8. [PubMed]

7. Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease. Huang JT, Chaudhuri R, Albarbarawi O, Barton A, Grierson C, Rauchhaus P, Weir CJ, Messow M, Stevens N, McSharry C, Feuerstein G, Mukhopadhyay S, Brady J, Palmer CN, Miller D, Thomson NC. Thorax. 2012 Jun;67(6):502-8. [PubMed]

8. Total desmosines in plasma and urine correlate with lung function. Lindberg CA, Engström G, de Verdier MG, Nihlén U, Anderson M, Forsman-Semb K, Svartengren M. Eur Respir J. 2012 Apr;39(4):839-45. [PubMed]

1. Increased circulating desmosine and age-dependent elastinolysis in idiopathic pulmonary fibrosis. de Brouwer B, Drent M, van den Ouweland JMW, Wijnen PA, van Moorsel CHM, Bekers O, Grutters JC, White ES, Janssen R. Respir Res. 2018 Mar 20;19(1):45. [PubMed]

2. The Effect of Vitamin K Antagonists on Rates of Elastin Degradation: Potential Implications for Chronic Pulmonary Diseases. I. Piscaer, N.E.A. Drummen, J.M. Van Den Ouweland, M.T.H. Spanbroek, L. Bloem-de Vries, F.M.E. Franssen, E.F.M. Wouters, C. Vermeer, R. Janssen. American Thoracic Society Meeting; 2017: Washington DC, US. Am J Respir Crit Care Med. 2017;A1053. [ATS abstract]

3. Circulating Desmosine Levels in Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease. R. Janssen, B. Robberts, M. Spanbroek, J.M. Van Den Ouweland, P. Zanen, P.A. Wijnen, C.H.M. Van Moorsel, W. Janssens, J.C. Grutters. American Thoracic Society Meeting; 2017: Washington DC, US. Am J Respir Crit Care Med. 2017;195:A2451. [ATS abstract]

4. The effects of endogenous and exogenous vitamin D on the rate of mature elastin degradation in COPD patients. Zaal R, Spanbroek M, Van den Ouweland J, Zanen P, Dekhuijzen R, Janssens W, Janssen R. European Respiratory Society Meeting; 2016: London, UK. [ERS abstract]

5. Low vitamin K status is associated with COPD and accelerated degradation of mature elastin. de Brouwer B, Spanbroek M, Drummen NE, Van den Ouweland J, Zanen P, Vermeer C, Janssen R. American Thoracic Society Meeting; 2016: San Francisco, US. Am J Respir Crit Care Med. 2016;193:A4134. [ATS abstract]

6. Short-term stability of the mature elastin degradation biomarker plasma desmosine and influence of smoking on plasma desmosine levels. Spanbroek M, Van den Ouweland J, Beijers T, Van Daal H, Dekhuijzen R, Janssen R. European Respiratory Society Meeting; 2015: Amsterdam, The Netherlands. European Respiratory Journal 2015;46 (suppl 59):PA3973.

7. Quantitation of Desmosine in Plasma by LC-MS/MS as Biomarkers for Elastin Degradation. van den Ouweland JMW, Spanbroek M, Janssen R, Beijers A, van Daal H. The Associations for Mass Spectrometry: applications to the Clinic Lab; 2015: Salzburg, Austria.

8. Quantitation of desmosine and isodesmosine in urine and plasma by LC-MS/MS as biomarkers for elastin degradation. van den Ouweland JMW, Spanbroek M, Janssen R, Beijers A, van Daal H. Ned Tijdschr Klin Chem Labgeneensk 2015;40:82-113.

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